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Our review was based on a systematic PubMed search of randomized controlled trials (RCTs), observational studies, systematic reviews/meta-analyses, literature reviews, and case reports, published up to 2022, evaluating the combined treatment with a GLP-1RA and a SGLT2i in T2DM or prediabetes

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L-carnitine boosts fat burning after exercise Supplementation of L-carnitine causes increased fat burning even after physical activity

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Semaglutide activates GLP-1 receptors involved in appetite regulation, gastric emptying, insulin signaling, and glucose metabolism

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